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75% of U.S. Banks Are Exploring Blockchain: Is Traditional Banking Going On-Chain?

Traditional banking is entering a new era as financial institutions accelerate their adoption of blockchain technology, tokenization and digital assets. At Money20/20 USA 2026 in Las Vegas, Remy Blaire speaks with Robin O’Connell, CEO of Uphold Enterprise, about the growing institutional demand for on-chain financial infrastructure, the convergence of traditional banking and decentralized finance, and how artificial intelligence could transform the future of financial services.

O’Connell highlights new research conducted by Uphold in partnership with American Banker, revealing that approximately 75% of surveyed U.S. financial institutions have digital asset initiatives underway. He explains why the industry is moving beyond experimentation, with roughly two-thirds of surveyed institutions allocating budgets to blockchain infrastructure and more than half issuing formal requests for proposals to potential technology partners. The findings demonstrate how banks, credit unions and other financial institutions are increasingly preparing to integrate digital assets into their operations.

The conversation explores how tokenization is expanding beyond cryptocurrencies and stablecoins into traditional financial products. O’Connell discusses the growing interest in tokenized deposits, money market funds and other financial instruments that can operate on blockchain networks. He explains why bringing these assets on-chain could improve accessibility, increase liquidity and enable financial transactions around the clock, while allowing the underlying technology to remain largely invisible to consumers.

Artificial intelligence and agentic commerce are another major focus as O’Connell examines the possibilities emerging from combining AI-powered financial assistants with programmable digital assets. He shares his perspective on how autonomous systems could eventually help consumers manage investments, compare financial products, optimize yields and access more personalized wealth management services. As financial assets become increasingly programmable, O’Connell explains why AI could fundamentally change how people interact with banks and investment platforms.

The discussion also examines the regulatory landscape surrounding digital assets in the U.S. and internationally. O’Connell highlights the importance of compliance as banks and financial technology companies expand their blockchain capabilities. He discusses the significance of the GENIUS Act, ongoing developments surrounding the CLARITY Act and regulatory guidance from agencies including the Securities and Exchange Commission and Commodity Futures Trading Commission. He also explains why companies must prepare for evolving regulatory requirements while continuing to develop new financial products.

Uphold’s enterprise infrastructure takes center stage as O’Connell shares how the company supports financial institutions seeking to introduce blockchain-based services. Drawing on more than a decade of experience in digital assets, Uphold provides technology supporting digital wallets, payments, liquidity and compliance. O’Connell explains how the company’s combination of retail operating experience and enterprise infrastructure allows banks and FinTech companies to access multiple capabilities without having to develop every component independently.

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